332 research outputs found

    The velocity of ball-carriers and tacklers during shoulder tackles

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    The most frequently executed type of tackle in rugby is the shoulder tackle. A shoulder tackle occurs when the tackler uses either shoulder as the first point of contact with the ball carrier. The aim of this study was to compare the velocity of the ball-carrier and tackler engaged in shoulder tackles, and determine whether factors such as the number of passes from the previous phase, match period, quality of attack, match location and position of tackler had an effect on the mean and approaching velocities of the ball-carrier and tackler. The velocity of the ball-carrier and tackler during shoulder tackles (n=12) were determined using a 2D analysis tool. The tackles were also coded according to pass number, match period, quality of defence and attack, match status, defensive shape and movement, position of tackler and ball-carrier. The ball-carrier's velocity (4.10±1.85m.s-1) when entering contact was significantly higher than the tackler's velocity (5.19±3.22 m.s–1)(p<0.05). The ball-carrier's velocity was significantly higher when entering contact further from the set piece (p<0.001), when playing away from home (p<0.001) and when ranked in the top three (p<0.001). The findings of this study provide insight into the complexities of the tackle in rugby

    Immune-mediated competition in rodent malaria is most likely caused by induced changes in innate immune clearance of merozoites

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    Malarial infections are often genetically diverse, leading to competitive interactions between parasites. A quantitative understanding of the competition between strains is essential to understand a wide range of issues, including the evolution of virulence and drug resistance. In this study, we use dynamical-model based Bayesian inference to investigate the cause of competitive suppression of an avirulent clone of Plasmodium chabaudi (AS) by a virulent clone (AJ) in immuno-deficient and competent mice. We test whether competitive suppression is caused by clone-specific differences in one or more of the following processes: adaptive immune clearance of merozoites and parasitised red blood cells (RBCs), background loss of merozoites and parasitised RBCs, RBC age preference, RBC infection rate, burst size, and within-RBC interference. These processes were parameterised in dynamical mathematical models and fitted to experimental data. We found that just one parameter μ, the ratio of background loss rate of merozoites to invasion rate of mature RBCs, needed to be clone-specific to predict the data. Interestingly, μ was found to be the same for both clones in single-clone infections, but different between the clones in mixed infections. The size of this difference was largest in immuno-competent mice and smallest in immuno-deficient mice. This explains why competitive suppression was alleviated in immuno-deficient mice. We found that competitive suppression acts early in infection, even before the day of peak parasitaemia. These results lead us to argue that the innate immune response clearing merozoites is the most likely, but not necessarily the only, mediator of competitive interactions between virulent and avirulent clones. Moreover, in mixed infections we predict there to be an interaction between the clones and the innate immune response which induces changes in the strength of its clearance of merozoites. What this interaction is unknown, but future refinement of the model, challenged with other datasets, may lead to its discovery

    South Africa's Socio-Techno Divide: A critical disourse analysis of government speeches

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    This paper aims at contributing to the debate about the digital divide. We first focus on what to us constitutes the root problem: the typical approaches to the development of people through and by the use of information and communication technologies (ICT). In contrast to governmental, political and technological attempts that focus almost exclusively on providing access to digital communication technologies, and expect "development" naturally to flow from that, we argue for a focus on "development" which is based on our notion of sustainable socio-economic development. We refer to "technocentric approaches" when the approaches propose and pursue technological interventions and show little regard for the actual needs of the people involved. At the other end of the scale, where the focus is on people and their developmental needs, we will speak of "sociocentric approaches". This presents us with a different divide, which we will refer to as the "socio-techno divide". We argue that it is this divide that has to be addressed - not the digital divide - and then present an analysis of the socio-techno divide. This analysis takes the form of two types of Critical Discourse Analysis (CDA), namely Foucauldian and Habermassian. The analysis of the South African government's rhetoric illuminates the issues that need our attention and indicates an agenda for constructive engagement about the use of ICT for development in the Third and Fourth worlds

    Properties of the conditionally filtered equations: Conservation, normal modes, and variational formulation

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    This is the author accepted manuscript. The final version is available from Wiley via the DOI in this record.Conditionally filtered equations have recently been proposed as a basis for modelling the atmospheric boundary layer and convection. Conditional filtering decomposes the fluid into a number of categories or components, such as convective updrafts and the background environment, and derives governing equations for the dynamics of each component. Because of the novelty and unfamiliarity of these equations, it is important to establish some of their physical and mathematical properties, and to examine whether their solutions might behave in counter-intuitive or even unphysical ways. It is also important to understand the properties of the equations in order to develop suitable numerical solution methods. The conditionally filtered equations are shown to have conservation laws for mass, entropy, momentum or axial angular momentum, energy, and potential vorticity. The normal modes of the conditionally filtered equations include the usual acoustic, inertio-gravity, and Rossby modes of the standard compressible Euler equations. In addition, they posses modes with different perturbations in the different fluid components that resemble gravity modes and inertial modes but with zero pressure perturbation. These modes make no contribution to the total filter-scale fluid motion, and their amplitude diminishes as the filter scale diminishes. Finally, it is shown that the conditionally filtered equations have a natural variational formulation, which can be used as a basis for systematically deriving consistent approximations.We are grateful to two anonymous reviewers for their constructive comments on an earlier version of this paper. This work was funded by the Natural Environment Research Council under grant NE/N013123/1 as part of the ParaCon programme

    Industrial bees: the impact of apicultural intensification on local disease 1 prevalence

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    This is the author accepted manuscript. The final version is available from Wiley via the DOI in this record.1) It is generally thought that the intensification of farming will result in higher disease prevalences, although there is little specific modelling testing this idea. Focussing on honeybees, we build multi18 colony models to inform how ‘apicultural intensification’ is predicted to impact honeybee pathogen epidemiology at the apiary scale. 2) We used both agent-based and analytical models to show that three linked aspects of apicultural intensification (increased population sizes, changes in population network structure, and increased between-colony transmission) are unlikely to greatly increase disease prevalence in apiaries. Principally this is because even low-intensity apiculture exhibits high disease prevalence. 3) The greatest impacts of apicultural intensification are found for diseases with relatively low R0 (basic reproduction number), however, such diseases cause little overall disease prevalence and therefore the impacts of intensification are minor. Furthermore, the smallest impacts of intensification are for diseases with high R0 values, which we argue are typical of important honeybee diseases. 4) Policy Implications: Our findings contradict the idea that apicultural intensification by crowding honeybee colonies in large, dense apiaries leads to notably higher disease prevalences for established honeybee pathogens. More broadly, our work demonstrates the need for informative models of all agricultural systems and management practices in order to understand the implications of management changes on diseasesBiotechnology & Biological Sciences Research Council (BBSRC

    How ownership rights over microorganisms affect infectious disease control and innovation: A root-cause analysis of barriers to data sharing as experienced by key stakeholders.

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    Genetic information of pathogens is an essential input for infectious disease control, public health and for research. Efficiency in preventing and responding to global outbreaks relies on timely access to such information. Still, ownership barriers stand in the way of timely sharing of genetic data from pathogens, frustrating efficient public health responses and ultimately the potential use of such resources in innovations. Under a One Health approach, stakeholders, their interests and ownership issues are manifold and need to be investigated. We interviewed key actors from governmental and non-governmental bodies to identify overlapping and conflicting interests, and the overall challenges for sharing pathogen data, to provide essential inputs to the further development of political and practical strategies for improved data sharing practices

    A single-column model intercomparison of a heavily drizzling stratocumulus-topped boundary layer

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    This study presents an intercomparison of single-column model simulations of a nocturnal heavily drizzling marine stratocumulus-topped boundary layer. Initial conditions and forcings are based on nocturnal flight observations off the coast of California during the DYCOMS-II field experiment. Differences in turbulent and microphysical parameterizations between models were isolated by slightly idealizing and standardizing the specification of surface and radiative fluxes. For most participating models, the case was run at both typical operational vertical resolution of about 100 m and also at high vertical resolution of about 10 m. As in prior stratocumulus intercomparisons, the simulations quickly develop considerable scatter in liquid water path (LWP) between models. However, the simulated dependence of cloud base drizzle fluxes on LWP in most models is broadly consistent with recent observations. Sensitivity tests with drizzle turned off show that drizzle substantially decreases LWP for many models. The sensitivity of entrainment rate to drizzle is more muted. Simulated LWP and entrainment are also sensitive to the inclusion of cloud droplet sedimentation. Many models underestimate the fraction of drizzle that evaporates below cloud base, which may distort the simulated feedbacks of drizzle on turbulence, entrainment, and LWP
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